· by castltrastondrs.medsky.network ·1d ago · view on bsky.app ↗

Will the mRNA flu shot work better than a regular seasonal one? What the science says (nature.com)

Moderna’s newly approved vaccine could allow manufacturers to respond more rapidly to changing influenza strains.

#Medsky🧪 #IDsky #publichealth @nature.com Early data shows that the newly approved mRNA flu vaccine works better than a regular seasonal shot, mFLUSIVA was tested on more than 20,000 adults in a clinical study ⏬️ flu cases by about 27% compared to standard vaccines … www.nature.com/articles/d41...

#idsky #medsky🧪#publichealth

2 comments — live from bluesky

TRAstonDrs · 1 · 1d ago

#vaccinesmatter mRNA is A Major Step Forward. Traditional flu shots require scientists to predict which strains will dominate more than half a year in advance so factories can grow the virus in chicken eggs. If the virus mutates during that time, the vaccine becomes a mismatch.

TRAstonDrs · 1 · 1d ago

Because mRNA vaccines are synthesized chemically, manufacturers can wait longer to see what strains are actually circulating and brew fresh batches in a matter of weeks. - People over 50+ especially those over 65 typically have weaker immune responses to traditional flu shots.

TRAstonDrs · 1 · 1d ago

- mFlusiva triggers significantly higher levels of virus fighting antibodies that persist for at least 6 months - While mFlusiva is more effective, data from @nejm.org highlights that it causes more frequent temporary side effects than traditional shots www.nejm.org/doi/pdf/10.1...

TRAstonDrs · 2 · 1d ago

🔥Common reactions: Injection site pain, fatigue, headaches, and fevers. 🔥Efficacy vs. Reactogenicity: Experts note that a stronger immune response often means a more noticeable reaction immediately after the shot www.nejm.org/doi/full/10.... comparators

TRAstonDrs · 2 · 1d ago

🔥 Clinical trial data demonstrated a relative vaccine efficacy of 26.6% against influenza-like illness compared to standard-dose

Terry T · 1 · 1d ago

I'll take two.