· by castltrastondrs.medsky.network ·1d ago · view on bsky.app ↗

Divergent responses to SARS-CoV-2 infection reveal brain resilience-associated astrocyte programs in centenarians (researchsquare.com)

Astrocytes were generated from PBMC-derived iPSCs of centenarians (≥100 years) who recovered from asymptomatic to moderate COVID-19 and from adults (<45 years) who experienced critical disease. Cells ...

#Medsky🧪 #IDsky #Neurosky #immunosky #publichealth #Vaccinesmatter An interesting study -This study refers to a breakthrough #neurobiology study exploring how the brains of centenarians (people aged 100+) possess intrinsic cellular resilience against #COVID . www.researchsquare.com/article/rs-1...

#covid #idsky #immunosky #medsky🧪#neurobiology #neurosky #publichealth #vaccinesmatter

1 comments — live from bluesky

TRAstonDrs · 1 · 1d ago

The study the study used induced pluripotent stem cells (iPSCs) to generate astrocytes—the crucial support cells of the human brain to compare the cellular responses of resilient older individuals with younger adults who suffered severe Covid

TRAstonDrs · 1 · 1d ago

The study evaluated the cells 48 hours post-infection using advanced quantitative proteomics and molecular profiling While both cohorts of #astrocytes were infected at similar rates, 🔥centenarian astrocytes mounted a highly controlled, quiet immune response.

TRAstonDrs · 1 · 1d ago

They secreted significantly lower levels of dangerous pro-inflammatory signals such as -CXCL8 (when fighting the original Wuhan strain). -CXCL10 (when fighting the harsher Gamma variant) 🔥 In contrast, astrocytes derived from the younger, severe cases showed widespread,

TRAstonDrs · 1 · 1d ago

chaotic dysregulation of stress and immune pathways. They also displayed elevated levels of NRP1 (Neuropilin-1 ,a protein linked to viral interactions without a corresponding protective benefit). The global protein remodeling caused by the virus was largely identical across both age groups.

TRAstonDrs · 1 · 1d ago

However, centenarian cells stood out due to a unique regulation of metabolic pathways and a reduced detection of antigen presentation-related proteins. This indicates that their cells successfully adapted their internal "fuel" production

TRAstonDrs · 1 · 1d ago

to survive the viral stress without triggering a self-destructive inflammatory cascade 🧨 #Astrocytes are responsible for maintaining brain balance, protecting neurons, and regulating CNS inflammation.

TRAstonDrs · 1 · 1d ago

In many standard COVID cases, hyper activated or damaged astrocytes trigger severe neuroinflammation, contributing to long-term neurological symptoms like "brain fog" & cognitive decline. pmc.ncbi.nlm.nih.gov/articles/PMC... pmc.ncbi.nlm.nih.gov/articles/PMC...

TRAstonDrs · 2 · 1d ago

This study proves that extreme longevity is accompanied by hardwired cellular programs that maintain brain resilience. By studying these specific centenarian astrocyte programs, The researchers hope to discover new therapeutic pathways to mimic this natural shield and protect

TRAstonDrs · 1 · 1d ago

the wider population from neurodegenerative damage caused by viral infections