Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death (cell.com)
Iron accumulation in tumors is well established, but how cancer cells tolerate its toxicity remains unclear. Jain et al. show that cancer cells adapt via a heme-SDH-CoQ axis that buffers iron-induced ...
#WeekendRead! #FerroptosisPower! #SmartTumor! Jain, Shah &co show @cp-cellmetabolism.bsky.social that colorectal cancer #CRC cells, that are addicted to #iron for their growth, use #heme to drive SDH & increase anti-ferroptotic CoQ, which can be targeted against CRC! www.cell.com/cell-metabol...
