Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions - Cell Death & Disease (nature.com)
Cell Death & Disease - Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions
🎉 Our new paper is out in Cell Death & Disease!
We show that CD44 in pancreatic CAFs links ECM remodeling to immunosuppression.
Loss of CD44 reduces fibrosis and Tregs, limits CAF-driven immunosuppression and improves T-cell killing.
www.nature.com/articles/s41...
